Dear ...
Thank you for responding to my request so quickly. Though I __(am/was)__ disappointed to hear that you are unable to __(speak at/emcee our/chair the…../etc.)__ __(type of event)__, I do understand that sometimes things just don’t __(fit into our schedules/work out/etc.)__. Perhaps __(I/we)__ can call on you another time.
I had actually thought of you first because of __(your talent as a…../the renowned work you do with…./etc.)__. And on that note, I intend to keep you on my list __(as a potential …../of gifted speakers/etc.)__ for future consideration. Again, thank you for your timely response, __(Name)__. __(I/We)__ wish you all the best.
Respectfully yours,